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super-resolution imaging

Increasing the success rate of CAR-T cell therapies using our robust in vitro assay to measure immunological synapse strength and durability

Our technology combines well with other immunocytotherapies and biologics, such as allogeneic NK cells, autologous BITES and modulated TCRs, and can be deployed in various parts of any pipeline, from early screening to post-manufacturing quality control.

Identifying effective condensate modulators for cancer therapeutics

Condensates compartmentalizing proteins and nucleic acids are often the location of dysregulation in cancer, and the pharmocodynamics of cancer therapeutics can be affected by condensates. However, while the CAR-T cell therapy field can now be considered fairly mature, we are only at the beginning of the process of leveraging an understanding of condensates to create effective condensate-targeting drug pipelines.

We deploy our live-cell super-resolution technology to determine the interaction of lead compounds and condensate components in intact cells. Our imaging at high-frequency and over extended durations gives us unparalleled input data for our machine learning algorithms, meaning novel insight into mode of action and lead optimization.