Pushing the boundaries of single-molecule imaging in living cells for drug discovery
New temporal and spatial dimensions to explore
Our technology combines well with other immunocytotherapies and biologics, such as allogeneic NK cells, autologous BITES and modulated TCRs, and can be deployed in various parts of any pipeline, from early screening to post-manufacturing quality control.
Condensates compartmentalizing proteins and nucleic acids are often the location of dysregulation in cancer, and the pharmocodynamics of cancer therapeutics can be affected by condensates. However, while the CAR-T cell therapy field can now be considered fairly mature, we are only at the beginning of the process of leveraging an understanding of condensates to create effective condensate-targeting drug pipelines.
We deploy our live-cell super-resolution technology to determine the interaction of lead compounds and condensate components in intact cells. Our imaging at high-frequency and over extended durations gives us unparalleled input data for our machine learning algorithms, meaning novel insight into mode of action and lead optimization.
High-frequency image capture rates
Extended durations: minutes, hours, even days
Without damage or artifacts unlike other super-res systems = Ultra-rich protein behavior data for AI analysis
Unprecedented platform for discovery
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