Pushing the boundaries of single-molecule imaging in living cells for drug discovery
Condensates compartmentalizing proteins and nucleic acids are often the location of dysregulation in cancer, and the pharmocodynamics of cancer therapeutics can be affected by condensates.
We deploy our live-cell super-resolution technology to determine the interaction of lead compounds and condensate components in intact cells. Our imaging at high-frequency and over extended durations gives us unparalleled input data for our machine learning algorithms, meaning novel insight into hit discovery, hit-to-lead, target identification, mode of action and lead optimization.
High-frequency image capture rates
Extended durations: minutes, hours, even days
Without damage or artifacts unlike other super-res systems = Ultra-rich protein behavior data for AI analysis
Unprecedented platform for discovery
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