These motion patterns, along with their localization (or mis-localization), give us "signatures" of the target protein activity. For instance signal transduction proteins which are part of an active signaling center have a distinct set of motion patterns compared with those which are inactive. The same applies to virtually any class of regulatory protein, and thus to potentially any candidate drug target. Local motions and broader movements tell us what the target is doing at any given point in time.
The challenge is in tracking these movements with enough resolution, both spatially and over time, to identify robust Space/Time-Activity Relationship models which connect motion signatures to target activity for any given target protein.
The Mizar Single-Molecule Tracking imaging system overcomes these challenges, employing patented technology for long duration, continuous tracking of target activity in any cellular compartment. We use this capability to follow target activity in real-time as drug candidates are added, powering hit classification for SAR-enabled drug discovery, target validation and MoA.
High-frequency image capture rates
Extended durations: minutes, hours, even days
Without damage or artifacts unlike other super-res systems = Ultra-rich protein behavior data for AI analysis
Unprecedented target activity platform for SAR-based discovery
"We value our technology, though certainly we value our people more, and that means valuing life outside of work as well as in it, understanding and respecting that we are each managing our own highly individualized and often complicated lives. Flexibility, consideration, and kindness - the things we want for ourselves are what we want for everyone in our group."
- Joel Smith, Co-Founder and CEO
"At Mizar, we pride ourselves in valuing the whole person, not just their productivity. We want people to bring their whole selves to their work. We believe all our different perspectives, experiences and knowledge contribute to the great work we do."
- Onjalé Scott Price, COO
We currently have no vacancies available. For more information on career opportunities please email us at Careers@MizarTx.com.
Or contact us using the form (required fields indicated by *).